Alcohol 'strongly linked to cancer', study finds

05 January, 2018, 14:34 | Author: Hope Soto
  • Budget 2017

The study also examined the body's mechanism of protecting itself against damage associated with alcohol exposures.

Patel: Our research suggests that alcohol causes cancer because, when the body breaks it down, it briefly converts it into acetaldehyde, which damages DNA if allowed to accumulate. The scientists were able to clearly find that the creation of acetaldehyde in the human liver permanently damages DNA in the blood stem cells.

To find out how it damages the body, scientists gave diluted alcohol to mice then sequenced their DNA and analysed their chromosomes.

The latest work showed that acetaldehyde slices through DNA, causing permanent damage, if the effects of the toxin are not neutralised by two natural defence mechanisms. This substance was found to be able to break down and distort DNA molecules within the blood stem cells.

"How exactly alcohol causes damage to us is controversial", study coauthor Ketan Patel of the Medical Research Council Laboratory of Molecular Biology tells The Guardian.

"The more that a person drinks, and the longer the period of time, the greater their risk of development of cancer, especially head and neck cancers..."

The breakthrough is claimed to explain how seven types of tumours form, including those of the mouth and throat, liver, colon, bowel and breast. Translating these results to humans means that, for some people, drinking alcohol could be exponentially more risky depending on their individual ability to process acetaldehyde. Even minimal drinking might cause some level of DNA damage.

North Korea to reopen key cross-border communication system with South Korea
Ambassador Nikki Haley told reporters at the United Nations. Fools, but talks are a good thing!" he said on Twitter. North Korea's call came half an hour later.


In the British scientists' study, when mice lacking the critical ALDH enzyme (ALDH2) were given alcohol, it resulted in four times as much DNA damage in their cells compared with mice with the fully-functioning enzyme. A group of enzymes breaks down a unsafe chemical that the body produces when it breaks down alcohol.

"This damage results in DNA double-stranded breaks that, despite stimulating recombination fix, also cause chromosome rearrangements", the scientists write. Millions of people worldwide either lack or carry faulty versions of these enzymes.

"Actually the blood system has a very stringent quality control mechanism to get rid of anything that is damaged", said Patel, adding that this might explain why alcoholics tend to become severely anaemic. While research in animals does not always translate to humans, we already know that alcohol is linked to cancer. This means that toxic acetaldehyde builds up in the body.

Previous research looking at the precise ways in which alcohol causes cancer has been done in cell cultures.

Professor Linda Bauld, Cancer Research UK's expert on cancer prevention, said: "This thought-provoking research highlights the damage alcohol can do to our cells, costing some people more than just a hangover".

With alcohol consumption causing contributing to an over 12,000 cancer cases annually in the United Kingdom alone, scientists warn it's high time people started thinking about cutting down on what and how much they drink.

Recommended:

  • All iOS and Mac devices affected by Meltdown and Spectre, Apple confirms

    All iOS and Mac devices affected by Meltdown and Spectre, Apple confirms

    The statement further adds that the company will release mitigations in Safari to help defend against Spectre. The company has said that it will release a patch to protect its browser, Safari, against Spectre.
    Photos show hardship and fun from massive winter storm on East Coast

    Photos show hardship and fun from massive winter storm on East Coast

    Most airlines have been letting customers change reservations without incurring a fee, usually up to $200 on USA flights . More than 40 flights have been cancelled at the Ottawa airport, as a major winter storm bears down on the East Coast.
    Man Charged with Sexually Assaulting Sleeping Spirit Airlines Passenger

    Man Charged with Sexually Assaulting Sleeping Spirit Airlines Passenger

    The horrified passenger woke up and allegedly found her shirt and trousers unbuttoned, and the man's hand inside her trousers . The new detail emerged Thursday during a hearing that ended with Prabhu Ramamoorthy detained without bond pending trial.
  • Nintendo Switch Now the Fastest-Selling Home Console in US History

    However, a reported delay in the manufacture of high-capacity Switch cartridges could restrict the flow of new games in 2018. The company has now increased its internal target for its first-year sales of the Switch to 16 million from 10 million.
    Rare 'blue supermoon' total eclipse to occur in Singapore on 31 January

    Rare 'blue supermoon' total eclipse to occur in Singapore on 31 January

    The phrase "once in a blue moon" - meaning something that does not happen very often - impresses how infrequent this event is. The night of 31st January 2018 shall mark the day when the " blue moon blood moon supermoon " shall shine high in the sky.
    Watch Justin Timberlake's New Video Co-Starring a 'Filthy' Robot

    Watch Justin Timberlake's New Video Co-Starring a 'Filthy' Robot

    The sci-fi flavored video - directed by Mark Romanek - is also as far away from the elements as you can possibly get. Now we know for sure: JT is releasing a new album on February 2, just a few days before his Super Bowl performance.
  • Look at These Incredible Photos of the SpaceX Falcon Heavy Rocket

    Look at These Incredible Photos of the SpaceX Falcon Heavy Rocket

    As SpaceX has pointed out, getting all 27 Merlin engines to ignite in unison is vital to the success of the launch. The mission was first added to SpaceX's manifest in October, with an initial launch slated for mid-November.

    Apple buys app development service Buddybuild

    Buddybuild will be joining up with the Xcode engineers over at Apple, in an effort to build even better apps and tools for iOS. Xcode is a software stack used by the Cupertino-headquartered company to develop software for iPhones and Macs.
    Kabul blast: Death toll rises to 20

    Kabul blast: Death toll rises to 20

    Kabul has been hit hard by terror attacks attributed to Taliban, Islamic State (IS), and other militants operating in the country. The Emergency Hospital in Kabul said in a tweet that at least 20 wounded were brought to the facility following the explosion .
  • Paladins is Adding a Battle Royale Mode Called Paladins: Battlegrounds

    Paladins is Adding a Battle Royale Mode Called Paladins: Battlegrounds

    Heroes will be able to hop onto their mounts and start exploring the map, looting all sorts of gear to take on other players. Players can play team deathmatch on the Trade District map, and this mode will be made available on January 10th.
    Tourist killed and 12 injured after HORROR balloon crash

    Tourist killed and 12 injured after HORROR balloon crash

    A sightseeing balloon carrying foreign tourists over Luxor in Egypt has crash landed on Friday. The pilot and one tourist survived by jumping from the balloon, officials said at the time.
    UK should introduce 'latte levy' on disposable coffee cups - MPs

    UK should introduce 'latte levy' on disposable coffee cups - MPs

    However, MPs criticised coffee chains for confusing customers by perpetuating the notion coffee cups are recyclable. You may not know it, but taxpayers (you and me) pay for 90 % of the cost incurred disposing of coffee cups.


Popular

Ryan Shazier making progress, regaining feeling in legs, father says
The 25-year-old Ryan Shazier underwent spinal stabilization surgery after the December 4 game in Cincinnati and has started rehab. Follow us on Twitter , Facebook and Instagram to stay updated with the latest news and exclusive giveaways!

Roy Moore Sued By One Of His Accusers
Corfman has not received any compensation from the Washington Post or from any other source for disclosing Mr. Corfman, and accused her of political motivations in speaking with The Washington Post: "I don't know Ms.

LG unveils 4K projector capable of outputting 150-inch projection
In fact, LG claims the ease with which the HU80KA projector can be used and installed happens to be the biggest USP of the device. In addition, the tech company has included a carrying handle, which makes the projector easier to hold and carry around.

Tesla Q4 2017 Vehicle Production and Deliveries
Tesla has disappointed production forecasts for its new Model 3 saloon amid continuing manufacturing troubles. The estimates for Model 3 deliveries by different brokerages varied widely.

North Korea nuclear bomb test accidentally destroys a City
A new report reveals a missile fired by North Korean military a year ago actually hit one of the nation's own cities. A USA government source says that a 2017 rocket launch failed and crashed into one of the country's own cities.

'Game of Thrones' to return in 2019 for final season
Game Of Thrones bosses have confirmed the final season will not air until 2019, and when it does come it will be short and sweet. This year-long gap will be the longest wait ever for fans desperate to know which character ends up in the coveted Iron Throne.

Salah crowned CAF African Player of the Year
Salah , 25, is expected to win the award for his contributions this season on both the club and global level. He also led Egypt to the final of the Africa Nations Cup last January, where they lost out to Cameroon.

Serena Williams Drops out of Australian Open
The 36-year-old explained: "My coach and team always said "only go to tournaments when you are prepared to go all the way". But the short turnaround after giving birth has proven too much for even the greatest player of her generation.

Nokia 6 (2018) to launch today in China
We had reported that this new device, a successor of the Nokia 6 which launched in 2017, was going to be launched on January 5 . The side profile is similar to what we have seen in the previous generation model launched a year ago and is robust as well.

Pak-US row: Parliamentary body to invite military leadership in next huddle
The US has been irked with the country since October when Pakistan had freed a Canadian-American family captured by militants. Pakistan's embassy in Washington did not immediately respond to a request for comment Thursday.