The study also examined the body's mechanism of protecting itself against damage associated with alcohol exposures.
Patel: Our research suggests that alcohol causes cancer because, when the body breaks it down, it briefly converts it into acetaldehyde, which damages DNA if allowed to accumulate. The scientists were able to clearly find that the creation of acetaldehyde in the human liver permanently damages DNA in the blood stem cells.
To find out how it damages the body, scientists gave diluted alcohol to mice then sequenced their DNA and analysed their chromosomes.
The latest work showed that acetaldehyde slices through DNA, causing permanent damage, if the effects of the toxin are not neutralised by two natural defence mechanisms. This substance was found to be able to break down and distort DNA molecules within the blood stem cells.
"How exactly alcohol causes damage to us is controversial", study coauthor Ketan Patel of the Medical Research Council Laboratory of Molecular Biology tells The Guardian.
"The more that a person drinks, and the longer the period of time, the greater their risk of development of cancer, especially head and neck cancers..."
The breakthrough is claimed to explain how seven types of tumours form, including those of the mouth and throat, liver, colon, bowel and breast. Translating these results to humans means that, for some people, drinking alcohol could be exponentially more risky depending on their individual ability to process acetaldehyde. Even minimal drinking might cause some level of DNA damage.
Roy Moore Sued By One Of His Accusers
Corfman has not received any compensation from the Washington Post or from any other source for disclosing Mr. Corfman, and accused her of political motivations in speaking with The Washington Post: "I don't know Ms.
In the British scientists' study, when mice lacking the critical ALDH enzyme (ALDH2) were given alcohol, it resulted in four times as much DNA damage in their cells compared with mice with the fully-functioning enzyme. A group of enzymes breaks down a unsafe chemical that the body produces when it breaks down alcohol.
"This damage results in DNA double-stranded breaks that, despite stimulating recombination fix, also cause chromosome rearrangements", the scientists write. Millions of people worldwide either lack or carry faulty versions of these enzymes.
"Actually the blood system has a very stringent quality control mechanism to get rid of anything that is damaged", saidPatel, adding that this might explain why alcoholics tend to become severely anaemic. While research in animals does not always translate to humans, we already know that alcohol is linked to cancer. This means that toxic acetaldehyde builds up in the body.
Previous research looking at the precise ways in which alcohol causes cancer has been done in cell cultures.
Professor Linda Bauld, Cancer Research UK's expert on cancer prevention, said: "This thought-provoking research highlights the damage alcohol can do to our cells, costing some people more than just a hangover".
With alcohol consumption causing contributing to an over 12,000 cancer cases annually in the United Kingdom alone, scientists warn it's high time people started thinking about cutting down on what and how much they drink.
Kabul has been hit hard by terror attacks attributed to Taliban, Islamic State (IS), and other militants operating in the country. The Emergency Hospital in Kabul said in a tweet that at least 20 wounded were brought to the facility following the explosion .
In fact, LG claims the ease with which the HU80KA projector can be used and installed happens to be the biggest USP of the device. In addition, the tech company has included a carrying handle, which makes the projector easier to hold and carry around.
The horrified passenger woke up and allegedly found her shirt and trousers unbuttoned, and the man's hand inside her trousers . The new detail emerged Thursday during a hearing that ended with Prabhu Ramamoorthy detained without bond pending trial.
As SpaceX has pointed out, getting all 27 Merlin engines to ignite in unison is vital to the success of the launch. The mission was first added to SpaceX's manifest in October, with an initial launch slated for mid-November.
This means users will be able to utilize Alexa to do things like control volume and change inputs with different voice controls. Manufacturing partners that have signed on to the program include GE Appliances, Kenmore, LG, Samsung, and Whirlpool.
The sci-fi flavored video - directed by Mark Romanek - is also as far away from the elements as you can possibly get. Now we know for sure: JT is releasing a new album on February 2, just a few days before his Super Bowl performance.
First, a very large and powerful storm will hammer coastal locations from Georgia to ME with ice and snow. In North Carolina, about 5,000 customers remained without power, down from a peak of about 20,000.
However, a reported delay in the manufacture of high-capacity Switch cartridges could restrict the flow of new games in 2018. The company has now increased its internal target for its first-year sales of the Switch to 16 million from 10 million.
Buddybuild will be joining up with the Xcode engineers over at Apple, in an effort to build even better apps and tools for iOS. Xcode is a software stack used by the Cupertino-headquartered company to develop software for iPhones and Macs.
A new report reveals a missile fired by North Korean military a year ago actually hit one of the nation's own cities. A USA government source says that a 2017 rocket launch failed and crashed into one of the country's own cities.
Coli breakout linked to romaine lettuce
So far 17 illnesses have been reported in the United States, including three in California, according to the CDC. He advises that people in these groups should be particularly vigilant about avoiding romaine lettuce.
'Game of Thrones' to return in 2019 for final season
Game Of Thrones bosses have confirmed the final season will not air until 2019, and when it does come it will be short and sweet. This year-long gap will be the longest wait ever for fans desperate to know which character ends up in the coveted Iron Throne.
Salah crowned CAF African Player of the Year
Salah , 25, is expected to win the award for his contributions this season on both the club and global level. He also led Egypt to the final of the Africa Nations Cup last January, where they lost out to Cameroon.
Chelsea to sign Ross Barkley from Everton for £15m
Barkley was out of contract at the end of the season, and could have left Everton on a free transfer. "I can't see that changing". Ross Barkley is getting closer to becoming a Chelsea player, according to the Telegraph .
Serena Williams Drops out of Australian Open
The 36-year-old explained: "My coach and team always said "only go to tournaments when you are prepared to go all the way". But the short turnaround after giving birth has proven too much for even the greatest player of her generation.