Breast cancer gene not linked to higher risk of death
14 January, 2018, 12:46 | Author: Terri Saunders
"This class of drugs has been used to treat advanced, BRCA-mutated ovarian cancer and has now shown efficacy in treating certain types of BRCA-mutated breast cancer", said Richard Pazdur, director of the FDA's Oncology Center of Excellence.
Despite the findings, the study authors caution that in the longer term, risk-reducing surgery should be discussed as an option for BRCA1 mutation carriers in particular, to minimise their future risk of developing a new breast or ovarian cancer.
Women under the age of 40 with breast cancer have the same chances of survival whether or not they've been diagnosed with a BRCA gene mutation, new research suggests. "While there is now no cure for metastatic breast cancer, today's approval offers a new, targeted option that may help to delay disease progression for these patients".
Lynparza was first approved by the FDA in 2014 to treat certain patients with ovarian cancer and is now indicated for the treatment of patients with breast cancer. "For the portion of the 155,000 women in the USA living with metastatic breast cancer who have an inherited BRCA mutation, today's news is encouraging".
The survival rates for both BRCA carriers and non-carriers were similar: after 2 years, the survival rates were 97% for carriers and 96.6% for non-carriers.
The BRCA1 and BRCA2 genes play a critical role maintaining the genetic stability of cells, and produce proteins responsible for repairing damaged DNA. Doctors had found that the star had mutations in BRCA genes which increase a woman's risk of breast cancer by four-to-eightfold.
FRIDAY, Jan. 12, 2018 (HealthDay News) - Lynparza (olaparib) has been approved by the U.S. Food and Drug Administration to treat metastatic breast cancer caused by a BRCA gene mutation. The trial measured the length of time the tumors did not have significant growth after treatment (progression-free survival). When evaluated against standard of care chemotherapy, the drug exhibited the ability to reduce the risk of disease progression or death by 42%.
The most frequently reported adverse events for olaparib included anemia, neutropenia, leukopenia, fatigue, nausea, vomiting, diarrhea, stomatitis, dysgeusia, respiratory tract infections, nasopharyngitis, and arthralgia/myalgia.
Dr. Susan M. Domchek, Executive Director of the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania and a national leader on the OlympiAD trials, said: "Patients diagnosed with BRCA-related metastatic breast cancer are often younger than other breast cancer patients, and their disease is often much more aggressive and hard to treat".
Its U.S. marketing application for same indication as ZEJULA is now under FDA review with an action date of April 6.
The pair last worked together on 2012's Django Unchained , when DiCaprio took a turn as shady plantation owner Calvin J. He had been serving a life sentence for ordering the murders of nine people including actress Sharon Tate .
Wonder Woman was named best action movie and star Gal Gadot accepted a special award for challenging gender stereotypes. The fantasy thriller was named Best Picture , while Guillermo del Toro picked up the prize for Best Director .
The Chicago Cubs and Kris Bryant came down to the wire with arbitration talks on Friday before 1 p.m.'s deadline. Donaldson and Toronto agreed at $23 million, the largest one-year deal for an arbitration-eligible player.
This is in comparison to the previously-used Harman Kardon audio technology that was seen on past TVs from LG in these lineups. But we would know more in the coming days with the prototype all set to be appearing at the show floor in CES.
One of the options to be discussed, he said, would be naval interdiction to stop North Korean smuggling. Trump would not confirm whether he has spoken with Kim, saying only that he didn't want to comment.
Record imports by state energy firms and higher Chinese production have pushed down domestic wholesale LNG prices in north China. Last month marked the first time since mid-2016 that imports grew slower than exports.
The Green Shirts lead the points table after registering back-to-back victories against Bangladesh and Nepal. The match was played at the Ujman Oval and the hosts were defeated by 7 wickets at the hands of the Indians.
However, the Lava Red 5T won't be any different when it comes to the regular 5T, which in our opinion isn't certainly bad. Good thing is, the OnePlus 5T Sandstone White costs as much as the original Midnight Black variant.
Trump says the "so-called bipartisan" deal "was a big step backwards" because it doesn't fund a wall along the Mexican border. Already past year , some Democrats had warned against negotiating with Trump, specifically on immigration.
Currently, Sam's Club operates 660 stores, but that number will be reduced by about 10 percent after the actions announced today. None of the closed Sam's Club locations are in the metro-east, including O'Fallon and Glen Carbon.
Cotton Bowl: Studs and duds in USC's loss to Ohio State
Normally, the winners of those leagues would face off in the Rose Bowl, but that is one of the national semifinals this season. From the beginning, the Trojans fell behind when Deontay Burnett fumbled the ball after a big first down.
Germany's Merkel makes breakthrough in bid to form coalition
With this agreement, Merkel has reproved her ability to resist - also physically - and to start arrangements late in morning. But after coalition talks between Merkel and two other parties failed to find an agreement, the SPD changed its stance.
Forecast: Cold today, snow possible Sunday
Temperatures will drop from the upper 20's for tailgaters to the low 20's by the time that Pats are celebrating their victory. Meteorologist Sarah Wroblewski said she expects the warning to be extended toward the coast as the cold front moves east .