Male infertility among many side effects linked to ibuprofen
10 January, 2018, 01:21 | Author: Hope Soto
The researchers also performed an analysis of adult testis explants to assess the direct effect of ibuprofen on the testis.
In the latest research, scientists looked at the impact of ibuprofen on 31 healthy young men over six weeks and performed further tests on cells and pieces of human testes in the lab. Ibuprofen lowered testosterone production in the tissues, but levels of the hormone remained the same in the men. Epidemiological studies have shown that NSAID exposure was associated with reduced testosterone and congenital malformations; another study showed a drop in a testosterone metabolite among men who were taking ibuprofen regularly.
There are new concerns that men who take a lot of Ibuprofen could face fertility problems. Essentially testosterone levels were normal but the men in the ibuprofen group had higher amounts of luteinizing hormone, which stimulates testosterone production.
The authors concluded that "we report a univocal depression of important aspects of testicular function, including testosterone production, after use of over-the-counter ibuprofen".
The study suggests that taking ibuprofen in doses common among athletes can lead to a hormonal condition linked to male infertility.
The disorder called "compensated hypogonadism" developed in the study participants within two weeks of having 600mg of ibuprofen twice a day.
Several experts have reacted to the study findings. "Based on these data, I personally would be very reluctant to take ibuprofen for longer than the 10 days normally indicated on the packet".
Over that time, there were no significant changes in the testosterone levels found in the blood of the subjects.
For now you don't need to worry unless you're a daily user of ibuprofen, and even then, more research will be needed before everyone's shouting about the dangers of painkillers. The consistency of the results, however, as well as the earlier epidemiological results, suggest that there might really be an issue here.
Before now, he says, "most warnings regarding this family of painkillers have focused on limiting long-term use in the elderly to prevent gastrointestinal, renal and cardiac adverse effects".
Compensated hypogonadism is typically found in older men, and it is linked with impaired fertility, according to the study.
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