Cancer "Vaccine" That Wipes out Tumors Ready for Human Trial
03 February, 2018, 03:32 | Author: Hope Soto
Stanford University researchers have demonstrated that injecting tiny amounts of two immune-stimulating agents directly into tumours in mice can eliminate all traces of cancer, in what could be a ground-breaking new approach for treating the deadly disease.
The method works for many different types of cancer, even in case of spontaneous tumors.
During the research, scientists find that a very little amount of these agents can work as a relatively cheap cancer therapy which unlikely gives way to some adverse side effects that get visible with bodywide immune stimulation.
"When we use these two agents together, we see the elimination of tumors all over the body", senior author Ronald Levy, M.D., professor of oncology, said in a statement.
This vaccine avoids the need to identify tumor-specific immunity targets and does not require the significant activation of the immune system, or to personalize the immune cells of the patient.
Of the two immune agents used in the study, one has already been approved for use in humans, and the second is now involved in a lymphoma treatment trial.
However, the new treatment harnesses the immune system's own ability to recognise cancer cells and infiltrate tumours.
While some approaches stimulate the entire immune system, others target certain areas to block the cancer from straying, and others (like the newly-approved auto T-cell therapy) removed immune cells from the body to genetically-engineer them. However, as the tumour grows, it often devises ways to suppress T cell activity.
Authors said the method works to reactivate the cancer-specific T cells by injecting microgram amounts of two agents directly into the tumor site. The first is a short piece of DNA called CpG oligonucleotide.
Secondly, an antibody binds to this receptor, activating the T cells so that they attack the cancer cells. Two different immune-stimulating compounds were injected into the tumor.
Levy and his colleagues tested their vaccine in more than 90 mice, some with a tumor transplanted into them and others that were genetically primed to develop cancer.
What's more, they said this approach worked for lymphoma, breast cancer, colon cancer and the deadly skin cancer melanoma.
A revolutionary cancer vaccine which triggers the whole body to attack tumours from one injection is to go into human trials. For mice with two tumors, injecting one tumor with the combination prevented the growth of the second one. The cancer recurred in some of the mice, but tumors regressed again after further treatment.
The researchers expect to start a small human trial including 15 people with lymphoma soon. If successful, he believes it could treat many types of tumors.
And because the agents are injected directly into the cancerous tumor, they are prescreened to recognize only cancer-specific proteins.
The research was supported by the National Institutes of Health (grant CA188005), the Leukemia and Lymphoma Society, the Boaz and Varda Dotan Foundation and the Phil N. Allen Foundation.
France coach Jacques Brunel names his side Thursday for its Six Nations opener at home to Ireland on February 3. France hooker Christopher Tolofua will miss the Six Nations championship because of a neck injury.
The ZenFone 5 Max will have a bigger battery while the Lite version is an affordable alternative for the entry-level segment. The debut of the gadgets will be held at the MWC in 2018, and ASUS has sent out invitations to this event.
He has two younger children, eight-year-old Benjamin and five-year-old Vivian, with his Brazilian supermodel wife Gisele Bündchen. Of the people who spoke to CBS2, no one questioned Brady's intentions toward his child.
Cowen reaffirmed a "buy" rating and set a $100.00 price objective on shares of Valero Energy in a research report on Thursday. Moreover, Tiemann Inv Advsr Limited Com has 0.21% invested in Valero Energy Corporation (NYSE: VLO ) for 3,235 shares.
After hitting all-time high on January 29, benchmark indices tumbled almost 3.5 per cent in just four trading sessions. Both the indices ended 2.7 per cent down for the week, which is their biggest weekly percentage drop since August 2017.
She subsequently stirs up controversy when she strikes up a relationship with a childhood friend, played by Rachel McAdams . Alluding to her true identity, Esti responds: "I think he felt that marriage would cure me".
The makers of Monopoly have announced the introduction of a cheaters' version of the classic property board game later this year. The objective of the game is the same: Be the player with the most money at the end, according to INSIDER .
Fights usually break out over the routes that migrants use to get into the United Kingdom , where they will claim asylum. The French interior minister has announced a visit to the port city to "take stock of the situation".
Police have so far arrested three persons in the Chandan Gupta murder case. "In Kasganj , there was no communal clash", he said. Uttar Pradesh Chief Minister Yogi Adityanath has announced an ex gratia of Rs 20 lakh to the family of Chandan Gupta.
That announcement came after Fisher spent the morning skating in full Predators gear on Wednesday morning at Bridgestone Arena. The NHL announced on Wednesday (Jan. 31) that Fisher has left retirement behind and is coming back to the Preds to play again.
Nintendo lays out six-title plan for Switch
Given that these are mostly 8- and 16-bit games, these upgrades will only be given where they are applicable. Nintendo had a hard time keeping the console on shelves for much of the year.
Spotify experiments with new playlist-streaming app
The app also includes the service's popular, individually personalized playlists such as Discover Weekly and Release Radar. Mashable reports that the ad-free app is created to help you get music on your speakers without breaking a sweat.
Windows 10 has officially surpassed Windows 7 worldwide
Also, taking inspiration from its flop predecessor Windows 8, Windows 10 offers built-in compatibility for more and more hardware. As of January 14, 2020, Windows 8.1, Windows Server 2016 or older and Windows 10 LTSC releases won't run ProPlus.