With a host of ex-Southampton players amongst the Liverpool ranks, not to mention the acquisition 5 weeks ago of £75M Virgil van Dijk, there is no doubt likely to be a febrile atmosphere at St Mary's Stadium.
Mo Salah and Roberto Firmino scored to pile on the misery for Pellegrino who admitted the fans have run out of patience with him.
Southampton responded well and exerted pressure on their visitors, with Pierre-Emile Hojbjerg forcing Karius into action from close range in the 18th minute.
And this is how things stayed for the remainder of the clash, with the Saints struggling to create clear-cut goalscoring opportunities over the course of the second-half, whereas Liverpool could easily have added to their goal tally through the likes of Salah, Firmino and Sadio Mane.
Karius, easily the busier of the two goalkeepers, was tested again just before the half-hour mark, halting Guido Carrillo's header from a James Ward-Prowse cross.
Firmino struck early after Southampton centre-back Wesley Hoedt's mistake, as the Dutchman horribly misjudged a Liverpool ball forward and gifted possession to the last player on the pitch that the Saints should allow to have the ball, Salah.
Liverpool should have put the game beyond Southampton 20 minutes from time when Firmino saw his effort saved by McCarthy and Salah put the rebound into the side-netting. Obviously, after the second goal, it was really tough for us to come back and, little by little, our confidence in the game was really down'.
Salah is proving to be the signing of the season as his goals, influence and general play have given something Liverpool have lacked for some time, and despite the fact he is not an out-and-out striker, he is scoring goals like one.
He said, "It's OK, but I would not say I'm satisfied".
Barlow and Weir met as teenagers and formed a lifelong friendship that took on a new level once Weir joined the Grateful Dead . A cause of death was not named, but NBC reports he was known to have health problems since suffering a heart attack in 2015.
It is the first time the two countries from the volatile Korean Peninsula have teamed up to perform together in the Olympics. Now, though, at age 33, he will step onto the ice wearing the colors of the United States of America at the Olympics.
The HomePod is one of the priciest home speaker models out there, priced just $50 less than the Google Home Max. Probably the most famous smart speaker is Amazon's Echo, which runs the AI assistant Alexa.
The diminutive guard's travels began after he was traded from the Boston Celtics to the Cleveland Cavaliers last August. By doing so, the Lakers were able to create enough cap space to pursue two max free agents this coming offseason.
Most of the precipitation in South Central Illinois is expected to be freezing rain, with a.12 inch accumulation projected. Starting Saturday evening, temperatures will fall into the low 30s and upper 20s from north to south.
Tributes have flooded in from across the world of football after the tragic passing of former and Celtic midfielder Liam Miller . Hailing from County Cork , the 36-year-old passed away following illness and will be sadly missed by his family and friends.
Ted Cruz - described the incident as "an attack". "Border Patrol Officer killed at Southern Border, another badly hurt". Customs and Border Protection's website , 38 agents have died in the line of duty since December 2003.
Doormen desperately tried to resuscitate her and paramedics arrived to give emergency treatment, but she sadly died at the scene. The undergraduate, from Hampshire, suffered a "serious head injury" which left her bleeding heavily on Wednesday night.
OxyContin has always been the world's top-selling opioid painkiller and generated billions in sales for privately-held Purdue. Although initially driven by prescription drugs, most opioid deaths now involve illicit drugs, including heroin and fentanyl.
Montana is gearing up for its second winter storm in less than a week, and it's expected to create big problems for travelers. The service predicts an accumulation of anywhere between 3 and 10 inches Thursday , depending on where the notice was posted.
Sheldon Wuttunee, former chief of the Red Pheasant First Nation, called on everyone to come together to solve their differences. Minister of Justice Jody Wilson-Raybould, said she was "committed to working every day to ensure justice for all Canadians".
THE 15:17 TO PARIS (not reviewed)
He was in the restroom preparing for the attack and stepped out to find a 28-year-old French banker, who first engaged the gunman. But as Stone and Sadler describe in their book, "Lisa told them she was from NY , and that she'd been in Venice for a few days".
Rory McIlroy misses cut to kick off busy PGA Tour stretch
McIlroy is making his first appearance in the event in which celebrity and corporate executive amateurs play alongside the pros. At stake on Sunday is a shot at his third victory at Pebble Beach that would strengthen his grip on No. 1 in the world.
Prince William jokes about expecting twins with wife Kate
However, William has jokingly revealed a small detail about Kate's pregnancy as he spoke to guests at a charity event last night. Two is fine, I do not know how I am going to cope with three, I am going to be permanently exhausted , ' the Prince replied.
Carlos Cordeiro elected as US Soccer Federation President
Soccer have announced that the organisation has three options regarding the vice-president position vacated by Cordeiro. Meanwhile, Solo also questioned the integrity of the Athletes Council, which voted in a group for Cordeiro.
North Korea invites South president
The proposed inter-Korean summit, if held, would be the third of its kind after those held in 2000 and 2007, both in Pyongyang. North Korean leader Kim Jong-un has invited his South Korean counterpart Moon Jae-in for a summit in Pyongyang, officials say.
Russian man duped US spies of USD 100000
An NSA spokeswoman said, "The NSA flatly denies that it paid any money to anyone as alleged in the New York Times story". There was no audio and no way to verify that the man seen in the video was Trump.
Klopp expecting a hot reception for Van Dijk at Southampton
Klopp also complimented the Southampton club for the work they do in nurturing players who have since gone on to join Liverpool . Joe Gomez seems likely to miss out with a knee problem, while Ragnar Klavan has returned to training after a muscle complaint.
Australia power to T20 victory over England
In 2014, a George Bailey-led side had registered a thumping eight-wicket win over England in a similar chase of 131. However, Chris Jordan, the Barbados-born cricketer, dismissed Lynn to ignite England's hope of a comeback.