With a host of ex-Southampton players amongst the Liverpool ranks, not to mention the acquisition 5 weeks ago of £75M Virgil van Dijk, there is no doubt likely to be a febrile atmosphere at St Mary's Stadium.
Mo Salah and Roberto Firmino scored to pile on the misery for Pellegrino who admitted the fans have run out of patience with him.
Southampton responded well and exerted pressure on their visitors, with Pierre-Emile Hojbjerg forcing Karius into action from close range in the 18th minute.
And this is how things stayed for the remainder of the clash, with the Saints struggling to create clear-cut goalscoring opportunities over the course of the second-half, whereas Liverpool could easily have added to their goal tally through the likes of Salah, Firmino and Sadio Mane.
Karius, easily the busier of the two goalkeepers, was tested again just before the half-hour mark, halting Guido Carrillo's header from a James Ward-Prowse cross.
Firmino struck early after Southampton centre-back Wesley Hoedt's mistake, as the Dutchman horribly misjudged a Liverpool ball forward and gifted possession to the last player on the pitch that the Saints should allow to have the ball, Salah.
Liverpool should have put the game beyond Southampton 20 minutes from time when Firmino saw his effort saved by McCarthy and Salah put the rebound into the side-netting. Obviously, after the second goal, it was really tough for us to come back and, little by little, our confidence in the game was really down'.
Salah is proving to be the signing of the season as his goals, influence and general play have given something Liverpool have lacked for some time, and despite the fact he is not an out-and-out striker, he is scoring goals like one.
He said, "It's OK, but I would not say I'm satisfied".
McIlroy is making his first appearance in the event in which celebrity and corporate executive amateurs play alongside the pros. At stake on Sunday is a shot at his third victory at Pebble Beach that would strengthen his grip on No. 1 in the world.
Later, he skipped a formal dinner at which he was due to share a table with North Korea's ceremonial head of state Kim Yong Nam . Otto had been in North Korea on an organized tour when he was arrested for allegedly stealing a propaganda poster from a hotel.
Iran sending a drone into Israeli airspace "demonstrates that our warnings were 100% correct", he added. Still, Israel has conducted dozens of covert airstrikes against Hezbollah weapons convoys in Syria .
Ted Cruz - described the incident as "an attack". "Border Patrol Officer killed at Southern Border, another badly hurt". Customs and Border Protection's website , 38 agents have died in the line of duty since December 2003.
NASA's New Horizons spacecraft recently turned its telescopic camera toward a field of stars, snapped an image - and made history. New Horizons is just the fifth spacecraft to speed beyond the outer planets, so many of its activities set distance records.
They would add a second-half three-pointer, while England would not score another point before the end of a brutal Test match. Eddie Jones has made two changes with Ben Te'o dropped as England get set to face Wales at Twickenham this Saturday.
Soccer have announced that the organisation has three options regarding the vice-president position vacated by Cordeiro. Meanwhile, Solo also questioned the integrity of the Athletes Council, which voted in a group for Cordeiro.
But during Friday's evening broadcast, Intel will also organize the drones to resemble a snowboarder racing down a slope. The performance requires three employees to monitor the drones, and Olympic volunteers to help set them up.
The HomePod is one of the priciest home speaker models out there, priced just $50 less than the Google Home Max. Probably the most famous smart speaker is Amazon's Echo, which runs the AI assistant Alexa.
Trump tweeted Friday morning that he had signed the bill, writing that the US military "will now be stronger than ever before". White House legislative affairs director Marc Short said the package would increase spending by "just shy" of $300bn (£216bn).
Tributes have flooded in from across the world of football after the tragic passing of former and Celtic midfielder Liam Miller . Hailing from County Cork , the 36-year-old passed away following illness and will be sadly missed by his family and friends.
An Apple spokeswoman told WFLA the company is investigating the incident and that it intends to reach out to Colon. The pair features a high-class W1 chip that allows for improved connectivity and easy pairing with the iPhone.
Major winter storm continues to pound US
Montana is gearing up for its second winter storm in less than a week, and it's expected to create big problems for travelers. The service predicts an accumulation of anywhere between 3 and 10 inches Thursday , depending on where the notice was posted.
THE 15:17 TO PARIS (not reviewed)
He was in the restroom preparing for the attack and stepped out to find a 28-year-old French banker, who first engaged the gunman. But as Stone and Sadler describe in their book, "Lisa told them she was from NY , and that she'd been in Venice for a few days".
Trump Urges Congress To End US Visa Lottery
Both have been involved with the group since previous year because they support a pathway to citizenship. They are people who came here as children; many know no other life than that in America.
Russian man duped US spies of USD 100000
An NSA spokeswoman said, "The NSA flatly denies that it paid any money to anyone as alleged in the New York Times story". There was no audio and no way to verify that the man seen in the video was Trump.
BU Skaters on Olympic Ice
It is the first time the two countries from the volatile Korean Peninsula have teamed up to perform together in the Olympics. Now, though, at age 33, he will step onto the ice wearing the colors of the United States of America at the Olympics.
Australia power to T20 victory over England
In 2014, a George Bailey-led side had registered a thumping eight-wicket win over England in a similar chase of 131. However, Chris Jordan, the Barbados-born cricketer, dismissed Lynn to ignite England's hope of a comeback.