Immune therapy key to extending lung cancer patients' lives
17 April, 2018, 18:46 | Author: Hope Soto
For the first time, a treatment that boosts the immune system greatly improved survival in people newly diagnosed with the most common form of lung cancer.
Leading researcher of this study, Dr. Leena Gandhi says 'What it suggests is that chemotherapy alone is no longer a standard of care.' she is the Thoracic Medical Oncology Program director for the Perlmutter Cancer Center at the New York University Langone Health.
Keytruda was approved previous year as an initial treatment with chemo for the most common form of advanced lung cancer, but doctors have been leery to use it because that was based on a small study that did not show whether it prolongs life.
Scientists at Johns Hopkins Bloomberg-Kimmel Institute for Cancer Immunotherapy and Memorial Sloan Kettering Cancer Center found that administering two doses of the anti-PD1 immunotherapy nivolumab for several weeks prior to surgery was not only safe but 45 percent of the patients in the trial responded so well that there was little evidence of the cancer remaining upon follow-up. He said that tumor cells were like bags of hidden proteins that, if exposed, the immune system could use as targets to find and attack cancer.
But patients in the immunotherapy group had more kidney problems, more immune-related adverse events and were more likely to stop treatment because of side effects. Keytruda and Opdivo each cost about $13,500 monthly per patient.
The study estimates that one year after treatment, 69 percent of patients who received the immunotherapy drug in addition to chemotherapy would still be alive, compared with 49 percent of people who received chemotherapy alone.
The study, a phase III clinical trial testing treatment effectiveness and side effects, included 616 patients at 118 medical facilities around the globe.
'We're not almost where we need to be yet, ' said Dr. Roy Herbst, a Yale Cancer Center lung expert who had no role in the studies. The studies were sponsored by the drugmakers, and many study leaders and Herbst consult for the companies. More research is needed to know if the combo improves overall survival, as Keytruda did.
The findings represent another step forward for immunotherapy, which has been making steady gains against a number of different cancers.
Rates of serious side effects were similar, but twice as many in the Keytruda group dropped out because of them. The median overall survival was 11.3 months in those who did not receive immunotherapy, whereas survival in the immunotherapy group was longer and the median has not yet been reached. The immunotherapy drugs did not help people with fewer tumor gene flaws.
Other studies presented at the meeting also highlighted advances in immunotherapy against lung cancer, but were at earlier points in the research and less likely to bring about immediate changes in medical practice. The estimated proportion of patients in the combination therapy group who were alive and whose disease had not gotten worse at a year was about 34 percent, about double the proportion for the chemo-only group.
Donaldson, ranked 51st and making his first appearance at the clay-court tournament, was jeered by the crowd on center court. I have a feeling that he missed me or tennis or both". "He's always there for me, knows me inside out".
That left Park two shots behind Henderson going into the seventh, but she fell further behind as she struggled to make birdies. Pernilla Lindberg shot 70 in her first start since beating Park in an eight-hole playoff in the year's first major.
Speaking on Sky Sports News, Dalrymple added: "He's a superb tactician, he's a superb strategist and he's a superb man-manager". Their success is not without controversy, however, following their tie-up with Portuguese super-agent Jorge Mendes.
The video shows several police officers in bicycle helmets, and what appears to be a uniformed supervisor inside the coffee shop. Addressing the issue forthrightly is important in part because Starbucks already has a complicated track record on racial issues.
Serzh Sargsyan , who held the office for almost a decade, had promised he wouldn't seek the key job of prime minister. The Civil Contract party PM also called upon his supporters to block streets and disrupt public transportation.
On Thursday, Shares of Facebook Inc ( NASDAQ: FB ) 2.73% and ended its trading session at $159.34. (NASDAQ: FB ) for 9,949 shares. Natl Pension Ser stated it has 1.90 million shares. (NASDAQ: FB ) shares with value of $221.33 million were sold by Koum Jan.
The US is "locked and loaded" if Syria uses chemical weapons again, America's United Nations envoy Nikki Haley said today. Prof Gillespie says the USA and its allies could have taken a different approach like imposing sanctions.
He said that that will contribute to the peace and stability of the Korean Peninsula. Song returned to Beijing without meeting Kim. Kim's wife, Ri Sol-ju, attended.
Police investigating fatal stabbing in London
A teenager has died after a stabbing in east London overnight as the capital continues to be gripped by a surge in knife-crime. Paramedics and London's Air Ambulance rushed to the address on Chestnut Avenue but the victim died at the scene.
Giant screens in Windsor for royal wedding
Since Prince Harry is not a direct heir to the throne, a formal guest list is not required, reports said. Germaine Greer says Meghan Markle will "bolt" when the reality of life as a royal sinks in.
Retooled Raptors ready for playoff rematch with Wizards
And, as Bradley Beal said, "DeMar (DeRozan) even made some threes in the fourth", which probably sounds a little harsh but ... The Toronto Raptors are averaging 114 points on 53.2 percent shooting and allowing 106 points on 47.7 percent shooting.
Jets ready for tougher test as series shifts to Minnesota
The concept of a whiteout was less fun for the Jets come Saturday, as they tried to make their way to the Twin Cities for Game 3. If the Wild doesn't want this series to end the way those did, this is a must win. "It's gonna be big", Eric Staal said.
Resignations of BJP ministers 'immediately accepted'
The Allahabad High Court also slammed the Uttar Pradesh Police for not taking appropriate action against the accused men. Mehbooba Mufti also chaired a meeting of Peoples Democratic Party (PDP) legislators and senior ministers in Srinagar.